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Evaluación de la actividad antifúngica y citotóxica de extractos, fracciones y aceite esencial obtenidos de las hojas de Origanum vulgare

dc.rights.licenseAtribución 4.0 Internacional (CC BY 4.0)spa
dc.contributor.authorGodoy Pérez, Lina María
dc.contributor.authorGómez Iriarte, Yeimi Johanna
dc.contributor.authorLaborde Velaides, Andrea Carolina
dc.contributor.authorMayorga Isaza, Álvaro Alfonso
dc.date.accessioned2022-11-29T22:26:55Z
dc.date.available2022-11-29T22:26:55Z
dc.date.issued2022
dc.identifier.urihttps://repositorio.juanncorpas.edu.co/handle/001/143
dc.description.abstractEl objetivo de este trabajo es evaluar la actividad antifúngica y citotóxica de los extractos de diferentes polaridades, aceite esencial y extracto por fluido supercrítico obtenidos de las hojas de Origanum vulgare. Se realizó un estudio experimental en el que luego de adquirir el material vegetal, se obtienen los extractos etanólico total (EET), éter de petróleo (EP), de diclorometano (ED), y metanólico (EM), además del aceite esencial (AE) y el extracto por fluido supercrítico (FS). Se evalúo la acción antifúngica de los anteriores extractos a concentraciones de 500, 250, 100, 50 y 10 μg/mL mediante el método de Kirby-Bauer de difusión en PDA con posterior medición del halo de crecimiento micelial de Botrytis cinerea; y para Fusarium oxysporum se utilizó el ensayo de medio modificado a microescala. Se tuvo como control positivo el itraconazol y como blanco PDA con Tween 20 al 5%. En paralelo se realizó la prueba de citotoxicidad en tres líneas celulares de cáncer: MDA-MB-231: Cáncer de mama, PC3: Cáncer de próstata y MCF-7: Cáncer de mama, a través del método del Bromuro de 3-(4,5- dimetiltiazol-2-ilo)-2,5-difeniltetrazol (MTT).spa
dc.format.extent81 hojasspa
dc.format.mimetypeapplication/pdfspa
dc.language.isospaspa
dc.publisherFundación Universitaria Juan N. Corpasspa
dc.rightsTodos los derechos reservados conforme a la ley. Se permite la reproducción citando fuente. El pensamiento que se expresa en esta obra, es exclusiva responsabilidad de los autores y no compromete la ideología de la Fundación Universitaria Juan N. Corpas.spa
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/spa
dc.subject.meshFitoterapia - Antimicrobianos
dc.subject.meshOrégano - Plantas medicinales - Investigación
dc.subject.meshMedicina Integradora y Complementaria
dc.titleEvaluación de la actividad antifúngica y citotóxica de extractos, fracciones y aceite esencial obtenidos de las hojas de Origanum vulgarespa
dc.typeTrabajo de grado - Especializaciónspa
dcterms.audienceComunidad Académica Universitariaspa
dc.contributor.subjectmatterexpertPombo Ospina, Luis Miguel
dc.contributor.subjectmatterexpertBorrego Muñoz, Paola
dc.contributor.subjectmatterexpertForero Supelano, Víctor Hugo
dc.description.degreelevelEspecializaciónspa
dc.description.degreenameEspecialista en Terapéuticas Alternativas y Farmacología Vegetalspa
dc.description.programEspecialización en Terapéuticas Alternativas y Farmacología Vegetalspa
dc.identifier.instnameFundación Universitaria Juan N. Corpasspa
dc.identifier.reponameRepositorio Institucional Fundación Universitaria Juan N. Corpasspa
dc.identifier.repourlhttps://repositorio.juanncorpas.edu.co/spa
dc.publisher.facultyEscuela de Medicinaspa
dc.publisher.placeBogotáspa
dc.relation.indexedRedColspa
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Molecules. 12 de octubre de 2021;26(20):6142.spa
dc.rights.accessrightsinfo:eu-repo/semantics/openAccessspa
dc.subject.proposalOriganum vulgarespa
dc.subject.proposalActividad antifúngicaspa
dc.subject.proposalActividad citotóxicaspa
dc.subject.proposalFusarium oxysporumspa
dc.subject.proposalBotrytis cinereaspa
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